In 1998, when reporting 2 cases of linear childhood CLE following the lines of Blaschko, Abe et al. Achromic naevus. Mosaicism describes an individual composed of two or more genetically different. Four other patterns of mosaicism are also discussed: blocklike, phylloid, large patches. 1 and 5. Correspondence to knownas Blaschko's lines. German dermatologist Alfred Blaschko is credited with the first demonstration of these lines in 1901. A diagram of the distribution pattern of these lines has since been drawn and is now referred to as the lines of Blaschko. Called the lines of Blaschko, or Blaschko lines, it’s thought they map the movements of cells from when the body was developing in the womb. Learn about Blaschko’s Lines, a type of skin cancer that affects the epidermis and dermis of the skin, and how it can be diagnosed and treated by Dr. German dermatologist Alfred Blaschko is credited with the first demonstration of these lines in 1901. Not the first to mention it but yeah Blaschko's lines aren't visible to anything normally. Blaschko's Lines. Incontinentia pigmenti (IP; Bloch-Sulzberger syndrome, MIM #308300) is an X-linked dominant genodermatosis that is usually lethal in males before birth [ 1-4 ]. One of the subjects developmental biologists are interested in is the development of pattern. The Blaschko’s lines result from the fact that some of a chimera's skin cells say “make darker skin” and some say “make lighter skin. They follow a dorsal “V” shape over the spine and back, an “S” shape over the lateral and anterior areas of the trunk, an arc from the chest to the shoulders, a spiral shape on the scalp, and a linear longitudinal pattern on the extremities. The lines of Blaschko were originally described by Alfred Blaschko in 1901. Blaschko lines presenting as narrow bands are common in mosaic disorders (e. 5%~1% of the population worldwide 1. Clinical features are heterogeneous. These lines are believed to be a result of the. A. This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. , 2008). The lines of Blaschko represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. Multiple lesions arise in a linear fashion along the lines of Blaschko, most commonly along a limb or one side of the trunk or head and neck ; Disseminated superficial actinic porokeratosis (DSAP) This is the most common variety and arises in. The lines of Blaschko were first described in 1901 by the German dermatologist Alfred Blaschko, who published a book comprising hand drawings of linear lesions of the skin from various parts of the body and a unique collection of 175 patients with epidermal naevi, sebaceous naevi, or naevus angiolipomatosus, as well as acquired. Lichen striatus is a rare, benign, self-limited linear dermatosis of unknown origin that predominantly affects children. The lines are V-shaped in the posterior midline (more so on the upper spine), inverted U-shaped on the chest and upper arm, S-shaped on the abdomen, and linear on the legs and lower arms. He noticed that some of his patients had skin disorders that followed a specific. ream@nationwidechildrens. Last updated October 06, 2023. These distinct types of archetypical arrangement should not. They were described and drawn by a German dermatologist, Blaschko, more than 100 years ago. 1A, B). 5 These lines are curved over scalp. 2) 3. Fig 2 Acne on the back at age 17 years, with more severe involvement in a blaschkoid distribution on the left. However, these lines can become visible if a person is suffering from a skin disease. Here we report a case of an 11-year-old female child presented with multiple hyperpigmented and hyperkeratotic papules present over the posterior aspect of right lower extremities along Blaschko’s lines. The lines are distinguished from other morphological lines of the skin and do not represent vascular, lymphatic or nervous structures. We are, in essence, walking mosaics. In 1901, the German dermatologist Alfred Blaschko described a system of cutaneous lines that represented the typical pattern that linear nevi appeared to follow. Yellow-brown hyperpigmentation following the Blaschko's lines. 1,2 There are several terms for this entity, including linear LP, Blaschkolinear LP, and Blaschkoid LP. Blaschko's lines are the most common pattern of mosaicism. These lines are consistently S-shaped on the abdomen, V-shaped on the upper spine, perpendicular along the length of the arms and legs, inverted U-shaped on the chest, and follows a more. Finally, we differentiate Blaschko's lines from other patterns on the skin such as. The lines are the little rings of growth as we developed I guess - this reminds me of the line patterns Farina and Epicuticular Wax. thought to represent pathways of epidermal cell migration and proliferation during the development of the fetus; become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. Blaschko’s lines are embryonal, epidermal cell lines distinct from the dermatome, and cutaneous lesions following Blaschko’s lines are a manifestation of cutaneous mosaicism [5]. The skin abnormalities that define each stage occur along lines of embryonic and fetal skin development known as Blaschko lines (see Figure 3). All humans have Blaschko’s lines, but they are usually not visible. Congenital lesions may include incontinentia pigmenti and variants of epidermal nevi. Multiple organ systems can be involved. Lichen planus; Blaschko’ lines; Lichen planus involving nails; Case report: Core Tip: Lichen planus (LP) with lesion distribution along the Blaschko’s lines can be differentiated from other skin lesions with linear distribution by dermoscopy and pathological biopsy. 62% of all LP patients. " While true (if overly simplistic) I can see how it might be a little unclear. Blaschko's lines were firstly described by Alfred Blaschko in 1910. They remind us of our individuality – that even within our own bodies, no two cells are exactly alike. Blaschko lines correspond to the path of embryonic cells as they grow outward from the dorsal midline toward the ventral. However, there is no report of. The lines trace how one cell in a baby divided and grew. To our knowledge, the dermatoscopic features of pigmented lesions in LWNH have not been described previously. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. Pigmentary mosaicism refers to patterned hypo- and/or hyperpigmentation that results from genetic heterogeneity of skin cells. They were described and drawn by Blaschko 75 years ago. The two. The lines of Blaschko represent a pattern assumed by several different nevoid and acquired skin diseases at the human skin and mucosae also do non match to any known nervous, vascular or lymphatic structures. Blaschko's lines were first described by Alfred Blaschko in 1901 and are thought to reflect patterns of cell migration and clonal expansion during the embryonic development of the epidermis [2. A dermatome is an area of skin that is supplied by a single spinal nerve. Treatment with 2% topical minoxidil twice a day produced gradual elongation and thickening of the affected hairs with considerable cosmetic. The lines of Blaschko describe a linear pattern of distribution of various congenital, nevoid, and acquired skin disorders with their suspected embryological origins not yet well understood. , 1984), not having the complexity of the lines and whorls, but are rather a series of broad linear bands which show a midline dip. Blaschko’s lines was reported by Richarz et al. 1). He noticed that some of his patients had skin disorders that followed a specific. TLDR. This concept was first introduced by the German dermatologist Alfred Blaschko at the 7 th Congress of German Dermatological Society in 1901. have reported the case of a 48-year-old patient with three clinical subtypes [ 12 ], while Vineet et al. Lichen planus is an uncommon disorder of unknown cause that most commonly affects middle-aged adults. Blaschko lines are consistently V-shaped on the upper spine, S-shaped on the abdomen, inverted U-shaped from the breast area to the upper arm, and perpendicular down the front and back of the lower extremities. Blaschko's lines, also called the lines of Blaschko, named after German dermatologist Alfred Blaschko, are lines of normal cell development in the skin. (A) Several small brownish erythema located linearly along Blaschko's line,Electronic address: Margie. They become. 线状苔藓是获得性、炎症性皮肤病，呈自限性，皮损线状排列，无其他症状，主要发生于儿童，一般单侧发疹，最常累及四肢，沿Blaschko线连续性或间断性分布。. These lines are only visible in those with a mosaic [1] [2] [3] skin condition or in chimeras where different cell lines contain different genes. Blaschko lines correspond with cell migration or growth pathways that are established during embryogenesis. thought to represent pathways of epidermal cell migration and proliferation during the development of the fetus; become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. In 55 (85%) children the skin lesions were confined to one side of the body, showing no preference for either left or right side. To the best of our knowledge, a similar clinical presentation has been. T-lymphocyte migration and clonal expansion in the course of embryogenesis of the skin could express the appearance of Blaschko’s lines. Typically these lines are not visible; however. The lines of Blaschko represent a nonrandom developmental pattern of the skin fundamentally differing from the system of dermatomes. Males and females have Blaschko's lines. [1][2][3] The lines can be observed in other animals such as cats and dogs. Blaschko’s lines are attributed to the migration lines of epidermal cells during embryogenesis and are characterized by a V-shaped pattern on the posterior midline, S-shape on the abdomen, and spiral on the posterior scalp. Over 100 years later, scientists agree the most likely explanation is that Blaschko lines trace the paths formed during embryonic development, as skin cells migrated and proliferated. They never cross the previous truncal middle line But run for it. The appearance of LPP in our case could not be directly linked to a specific cause because of the ambiguity in the pathogenesis of the disease. Patches around the palpebral and other fissures like periorbital, perinasal, perioral, and periaural were more common. Blaschko: Die Neven-verteilung in der Haut in ihrer Beziehung zu den Erkrankungen der Haut. The appearance of LPP in our case could not be directly linked to a specific cause because of the ambiguity in the pathogenesis of the disease. Swirling patterns around the trunk and linear patterns down the legs and arms are referred to as Blaschko's lines; Lesions first appear as small 0. These skin cells go rapidly in groups along these Blaschko’s lines as the fetus develops. Since 1901, when Blaschko lines were first described, the study of mosasicism has helped to elucidate the. Neither a specific disease nor a predictable symptom of a disease, Blaschko's lines are an invisible pattern built into human DNA [citation. Blaschko’s lines are attributed to the migration lines of epidermal cells during embryogenesis and are characterized by a V-shaped pattern on the posterior midline, S-shape on the abdomen, and spiral on the posterior scalp. TLDR. Notably, this is distinct from fine and whorled Blaschko's lines (Blaschko, 1901; Happle et al. Alfred Blaschko is credited with the first demonstration of these lines in 1901. B, Equivalent. Blaschko’s lines. They are clinically important, as many inherited and acquired diseases follow these lines, making a characteristic visual appearance. 4 The pattern is attributed to lines of migration of epidermal cells during embrogenesis. The stripes are sort of U-shaped down our fronts and V-shaped on our backs, wavy on the head and face and we have basic simple stripes on our extremities. According to this result, the linear hypomelanotic lesions along Blaschko's lines in HI may develop as a consequence of mosaicism of epidermal cells. It is also important to mention that not all XX/XY individuals are chimeras. The visual appearance of X-linked skin disease can follow the pattern of lines described by the dermatologist Alfred Blaschko. Moderate papillary dermal edema was present, along with focal homogenization of the collagen and. This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. 62% of all patients. The most widely accepted basis for these lines is. It is solitary in 50% of cases and may follow Blaschko lines. Alfred Blaschko is credited with the first demonstration of these lines in 1901. Blaschko’s lines don’t affect the body. Cutaneous lesions following Blaschko lines are a manifestation of cutaneous mosaicism. Expand [PDF] Save. 2. A diagram of the distribution pattern of these lines has since been drawn and is now referred to as the lines of Blaschko. Blaschko, in 1901, meticulously recorded these lines that do not follow any known nervous, vascular, or lymphatic structures in the skin. Citation 58 Linear or zosteriform LP is an uncommon variant that follows the Koebner phenomenon, does not adhere to Blaschko’s lines, and rarely follows a dermatomal arrangement. The objective of this study was to consider a hypothesis of the existence of Blaschko lines in the CNS in the example of incontinentia pigmenti (IP). The stripes on humans are called Blaschko’s lines,. 1, 2 The nevi are generally unilateral, following Blaschko lines in linear. The distribution of skin conditions along Blaschko’s lines that involve dermal processes is thought to be due to epidermal mutations that lead to changes in dermal tissues. CDR_112_20. A. BACKGROUND Linear atrophoderma of Moulin (LAM) is a dermatosis that affects children and adolescents characterized by hyperpigmented and atrophic. Yeah, there were multiple things of vanilla ice cream and now they're one thing, but it's all vanilla ice cream. It is classified into two major types, segmental and non-segmental, with the latter including several subtypes (generalized vitiligo, acrofacial vitiligo, and. 6 Dispersed lesions of classical lichen planus can also occur over the Blaschko lines. Lichen striatus is clinically diagnosed on the basis of its appearance and characteristic developmental pattern following the lines of Blaschko. The system of Blaschko's lines on the head and neck as elaborated by this study is more precise than previously published diagrams and shows definite crossing of lines. Thomas et al. Lesions can appear anywhere, but the sites most commonly affected are the fingers and wrists, axillae, groin, and genitalia, and the skin around the eyes and mouth. Blaschko’s lines. Very sophisticated. For a wider selection of files connected with Blaschko's lines, patterns 3D shaded true SVG, see Category:Blaschko's lines, patterns. The genetic mosaicism in an acquired Blaschko-linear inflammatory dermatosis could be accountable for the cutaneous antigenic mosaicism that can prompt a mosaic T-cell response based on the trigger of. In the present instance, the linear erythema resolved promptly in response to primary IVIG therapy as with the other KD symptoms, suggestingThese preliminary results support the ideas that (1) Blaschko's lines represent single clones of epidermal cells; (2) in patients with HI and severe neurological involvement mosaicism, if detectable, is best shown in keratinocytes; and (3) the cytogenetic defect in epidermal cells may be directly responsible for the failure of pigmentation in HI. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. Mosaicism describes an individual composed of two or more genetically different. Lines of Blaschko doi: 10. As its name would suggest, the skin lesions occur along Blaschko lines. Blaschko's lines represent the pathways of epidermal cell migration and proliferation during fetal development. In heterozygous females affected by an X-linked skin disorder, lesions often appear in a characteristic pattern, the so-called Blaschko's lines. Most commonly affect the scalp, then the preauricular region, face, and neck. The most common clinical patterns are streaks and swirls following Blaschko's lines in narrow or broad bands and a block-like distribution. These lines were painstakingly and thoroughly documented first by German dermatologist Alfred Blaschko. When there is a big difference between the two. To minimize confusion and be more consistent with its distribution, we suggest this. Together with new insights on the role for lysosomal signalling in embryonic stem cell differentiation, mutations in the X-linked transcription factor 3 (TFE3). , BMC Medical Genetics , 2011 ) Mutations involving color-producing cells can lead to pigmentary mosaicism presenting as streaks and swirls following Blaschko lines. It is particularly common in children and rarely seen in adults. On the trunk and limbs the linear arrangement is usually easily distinguishable, but recognizing that a small lesion on the face follows Blaschko lines can be difficult in some patients (eg, the epidermal nevus represented in Fig 1, A. Dossi Cataldo et al. 24%-0. They. This contribution provides an update on the diverse genetic etiologies. We also include cutaneous disorders that have a linear distribution but do not follow Blaschko's lines. 1016/B978-0-444-62702-5. Lichen striatus is an acquired, asymptomatic, and self-limited linear inflammatory skin disorder that predominantly affects children [ 1,2 ]. Streaks of hypopigmentation or hyperpigmentation along the lines of Blaschko have been named hypomelanosis of Ito (HI) and linear and whorled nevoid hypermelanosis (LWNH) []. JAMA Dermatology ( IF 10. 3. were the first to describe a seemingly unidentified entity characterized by the presence of hyperpigmented and atrophic band-like lesions that closely followed Blaschko’s lines []. We describe the first reported case of childhood linear DLE. Three months later, the proband had several verrucous changes ( Figure 1B )], hyperpigmented maculas, and very few vesicles. different dermatoses, but the cause of this Revised version accepted 3 June 1993. lines of Blaschko: ( blahs'kō ), a pattern of distribution of skin lesions or pigmentary anomalies; linear on the extremities, S-shaped curves on the abdomen, and V-shaped. We describe the first reported case of childhood linear DLE following the lines of Blaschko. Approximately 10% of patients with LP. Finally, we differentiate Blaschko's lines from other. He noticed that some of his patients had skin disorders that followed a specific. Several examples of chekerboard or patch patterns on human skin are seen in several human diseases (Happle, 1995, 2004). Nevertheless, this should be considered in the differential diagnosis of any macular hyperpigmentation. The lines of Blaschko represent a pattern followed by many skin disorders. LPP along Blaschko's lines has been associated with susceptibility to genetic mosaicisms. have described linear and zosteriform lesions that were lateralized to the right side of the body along the lines of Blaschko. Blaschko’s lines map out a migratory history of ectodermal skin cells after their proliferation and movement from embryonic development into the fully formed organism ; further, skin disorders following these lines may be explained by the mosaicism due to X-chromosome inactivation or early somatic mutations . They were described and drawn by Blaschko 75 years ago. It presents as a pink rash with raised spotting that comes together to form singular or multiple, dull-red, potentially-scaly linear bands that affect the Blaschko lines. This work describes the first reported case of childhood linear DLE following the lines of Blaschko, and a review of the linear manifestations of childhood LE is presented. This characteristic skin lesion. HISTORICAL OVERVIEW. These lines, which form V patterns on the back and S patterns on the stomach, are a consequence of the way embryonic cells proliferate. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow these lines. The present author previously proposed that in addition to the line of migration, proliferation pattern of the embryonic cells at some later stage might have. Although in the initial description 1 extracutaneous findings were not reported, HI was later recognized as a. He was otherwise healthy with no family history of au-toimmune diseases. The lines of Blaschko represent a pattern followed by many skin disorders. These diseases are hypothesized to be caused by genetic mosaicism resulting from processes such as lyonization or somatic postzygotic mutation. Human skin is overlaid with what dermatologists call Blaschko’s Lines, a pattern of stripes covering the body from head to toe. Blaschko’s lines are named after Alfred Blaschko, a German dermatologist who first described them in 1901. Results. Unilateral distribution of lesions in arm, leg. Noun [edit] Blaschko's lines pl (plural only) Lines of normal cell development in. ”. However, these lines can become visible if a person is suffering from a skin disease. Numerous skin conditions, including genodermatoses, nevi, and inflammatory disorders can present along Blaschko lines. Blaschko’s lines, also called the lines of Blaschko, named after Alfred Blaschko, are lines of normal cell development in the skin. They were described and drawn by Blaschko 75 years ago. Keratinocytic epidermal nevi are also known as linear epidermal nevi or verrucous epidermal nevi, based on characteristics of their appearance. 1016/s0190-9622 (94)70143-1. The peripheral rim can be translucent or slightly pigmented and centre can have dotted vessels or blue/gray dots/granules based on the. Like dermatomes, they are linear on the limbs and circumferential on the. Blaschko’s lines are attributed to the migration lines of epidermal cells during embryogenesis and are characterized by a V-shaped pattern on the posterior midline, S-shape on the abdomen, and spiral on the posterior scalp. We also include cutaneous disorders that have a linear distribution but do not follow Blaschko's lines. 6 (1):p 56, Jan–Jun 2022. When we start out as a single cell, and then a ball of cells, some of these cells become skin cells. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. Histological examination was compatible with the clinical features. Blaschko lines correspond with cell migration or growth pathways that are established during embryogenesis. Start your 7-day free trial to. Bhutani et al. There have been many reports of congenital and acquired. Danarti et al 4 postulated that LAM may reflect the action of an autosomal lethal gene surviving by mosaicism. 4 Blaschko lines are invisible in normal skin but may become apparent in various skin conditions. We also include cutaneous disorders that have a linear distribution but do not follow Blaschko's lines. Blaschko线是以首次描述这些线的人名字命名的。. genital and are arranged in a linear fashion following Blaschko’s lines. Background: The system of Blaschko's lines has been insufficiently documented on the head and neck. Jochen, a dermatologist and. Some acne-like horny plugs in the center of the papules merge into plaques. Dermatoscopy can be used in the differential diagnosis of this pigmentation disorder. The lines of Blaschko represent a pattern followed by many skin disorders. 2Atrophic, squamous, and erythemato-violaceous plaques following Blaschko’s lines were noted on her left knee . However, these lines are invisible in most people. Blaschko Lines follow the same pattern on all people. BACKGROUND Lichen planus (LP) with distribution of lesions along Blaschko’s lines is a rare entity, accounting for 0. There have been many reports of congenital and acquired dermatosis that. Somatosensation includes feedback from mechanoreceptors, thermoreceptors, proprioceptors, pain receptors, and chemoreceptors. Blaschko's lines were delineated in 1901 by a German dermatologist Alfred Blaschko . We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow. Jun 21, 2020 - Blaschko lines - Are humans striped? It looks they are and it is called Blaschko lines. Linear atrophoderma of Moulin is a rare subtype of atrophic and pigmented linear morphoea. Introduction. 5. 10. They follow a “V” shape over the back,. The lines of Blaschko delineate the lines of migration of epidermal cells during embryogenesis. . Incontinentia pigmenti, also known as Bloch-Sulzberger syndrome, is an uncommon sex-linked inherited syndrome reported primarily in females, as it is often lethal to male fetuses in utero. These lines are to be distinguished from other linear patterns such as Voight's lines, Langer's lines, and the lines of innervation of the spinal nerves. We also include cutaneous disorders that have a linear distribution but do not follow Blaschko's lines. Lichen striatus is clinically diagnosed on the basis of its appearance and characteristic developmental pattern following the. Kawasaki disease (KD) is a self-limited, systemic vasculitis developing in early childhood. These lines, which are invisible under normal conditions, indicate the normal. Most of them are nevoid skin lesions present at birth or having a later onset: epidermal nevi (naevus unius lateris, linear porokeratosis), adnexal nevi (linear sebaceous nevus, linear. Of all ACC cases, 70% are single lesions, 20% are double, and 8% are triple. These lines create a surface pattern which is distinct from other morphological lines. Various chromosomal anomalies have been identified in. Beilage zu den Verhandlungen der Deutschen Dermatologischen Gesellschaft VII Congress, Breslau, 1901. The lines of Blaschko represent a pattern followed by many skin disorders. Uninterested because of frequent exposure or indulgence. Nails of the left hand were also affected (Fig. SUMMARY. Fig. These lines are. Blaschko’s lines. The diagnosis and management of lichen. A 24‐year‐old woman with a 3 year history of Blasehkitis is presented with a dermatosis consisted of erythematous vesicular papules following BlaseHko's lines on her left trunk, which demonstrated a perivascular inflammatory infiltrate in the subpapillary dermis with lymphocytic exocytosis. Blaschko’s lines (BL) are considered systematized cutaneous developmental patterns during embryogenesis that are different from vascular, neural, or lymphatic pathways. They were described and drawn by Blaschko 75 years ago. The lines of Blaschko represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. , incontinentia pigmenti). The lines of Blaschko, which are normally invisible on skin, are thought to follow the paths along which cells migrate as the skin develops before birth. The original description by Blaschko referred to a system of lines on the human skin which the linear naevi and dermatoses follow. The lines of Blaschko represent the routes of ectodermal cell migration from the neural crest. Trunk - they differ from dermatomes in being more numerous and wave-like on the lateral. 4 Blaschko’s original diagrams did not include the lines of the face or scalp; however, the pattern now accepted was later depicted by Happle in 2001 (Figure 6). 2011. Blaschko's lines are attributed to the migration lines of epidermal cells during embryogenesis and are characterized by a V-shaped pattern on the posterior midline, S-shape on the abdomen, and. (A) Blaschko lines distributed lesions (2-weeks-old). Iijima et al. This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. Case summary: A 20-year-old woman presented. They curve around the sides, like tiger stripes. These lines are to be distinguished from other linear patterns, such as Voight's lines, Langer'sBlaschko’s lines, also called the lines of Blaschko, named after German dermatologist Alfred Blaschko, are lines of normal cell development in the skin. [] However, some cases of LS showing bizarre. Two years later, Baumann et al. Lichen planus may affect the skin (cutaneous lichen planus), oral cavity (oral lichen planus), genitalia (penile or vulvar lichen planus), scalp (lichen planopilaris), nails, or esophagus. A case of erythema multiforme along Blaschko’s lines is reported in a 20-year-old female suffering from recurrent herpes labialis. Blaschko, in 1901,. The lines of Blaschko represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. British Journal of Dermatology. A major differential diagnosis is inflammatory linear verrucous epidermal nevus (ILVEN). They become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. Linear and whorled nevoid hypermelanosis (LWNH) is a rare sporadic pigmentary anomaly, characterized by swirls and streaks of macular hyperpigmentation following the lines of Blaschko, without preceding inflammation, and is usually seen in the first 2 years of life. These lines are to be distinguished from other linear patterns such as Voight's lines, Langer's lines, and the lines of innervation of the spinal. Citation 58 Linear or zosteriform LP is an uncommon variant that follows the Koebner phenomenon, does not adhere to Blaschko’s lines, and rarely follows a dermatomal arrangement. [2,3] In contrast to dermatomes, Blaschko's lines form a V-shape over the spine and an S-shape on the lateral and anterior aspects of the trunk. Very few cases of bilateral. 1 He originally described these lines as “a system of lines on the human skin that linear nevi and dermatoses follow”. 1, 2, 3 The term linear LP was first used in 1976 to describe lesions along the lines of Blaschko, demonstrating a characteristic S shape on the abdomen, V shape near the. To test the. As its name would suggest, the skin lesions occur along Blaschko lines. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow these lines. Lichen striatus is a rare, benign, self-limited linear dermatosis of unknown origin that predominantly affects children. The lines of Blaschko are a pattern of lines on the skin that represent the developmental growth pattern during epidermal cell migration. Blaschko's lines form a pattern, which many diseases are found to follow, but linear scleroderma following Blaschko's lines is a controversial entity rarely reported in the literature. 1. Although cases of lichen planus (LP) are not uncommon, LP with lesion distribution along the Blaschko’s lines is a rare entity, accounting for only 0. Blaschko’s lines are actually traces of the migration and proliferation of skin cells during embryonic development. What are Blaschko Lines and what do they look like? Blaschko lines are markings that can be found on the skin of some people. There was high degree of similarity in the shape, orientation, and pattern of these idiopathic pigmented patches with the same of many pigmentary nevi, Blaschko's line of face and with the recently described specific Blaschko's lines for pigmentary nevi as well [Figure 10]. On the chest and upper back, they rise in a swirl before dipping down to meet in a deep “V” along the spine and the middle of the chest. This is a review of case reports providing photographically documented evidence that the lines of Blaschko become manifest in. Blaschko's lines. They differ from dermatomes, and appear as single or multiple lines, whorls (swirls) and wave-like shapes in the skin. Unilateral distribution of lesions in arm, leg, trunk, and waist is even less common. Dermatomes are different from Blaschko lines. How To Pronounce Lines composed a few miles above Tintern Abbey, on revisiting the banks of the Wye during a tour, July 13, 1798 How To Pronounce Lines Composed a. To recap, since 2012 or earlier, waves of social media users searched for “humans have stripes,” “humans have invisible stripes,” or “Blaschko’s lines,” likely landing on Wikipedia’s. The BL were described and drawn by Alfred Blaschko, a German dermatologist, in 1858-1922 [ 1, 2 ]. The main purpose of this article is to introduce the concept of Blaschko's lines into the medical, paramedical, and general biological fields of science, and it is hoped that some inter‐reaction can occur between those who regularly see and study other chromosomal and embryological abnormalities. Early lesions which are erythematous/bullous evolve over time into warty lesions, hyperpigmented swirls/macules, and atrophic hypopigmented streaks. Blaschko′s Lines. Line of Blaschko. (B) verrucous formation on the middle digit (3-months-old). The lines of Blaschko represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. 1 Because many skin disorders that followed these lines were present at birth, Blaschko suspected that they had an embryonic origin. Finally, we differentiate Blaschko's. Exogenous linear patterns are caused by external factors. 11 The lines are visible and present in S-shaped, V-shaped, or even U-shaped patterns. comedone-like pits coronoid lamellaIn an infant or young child, a nevus sebaceous (sebaceous naevus) presents as a solitary, smooth, yellow-orange hairless patch or plaque, often oval or linear in shape. A diagnosis of scalp mosaicism associated with widespread cutaneous mosaicism due to systematized sebaceous nevus was made. Epidermal nevi occur in one out of 1,000 live births, and 80 percent of cases appear in the first year of life. Four other patterns of mosaicism are also discussed: blocklike, phylloid, large. Cutaneous mosaicisms usually manifest by specific patterns on the skin and the archetypic pattern is the system of Blaschko lines, but others include checkerboard, phylloid, large patches without midline separation and lateralization. Blaschko’s lines are invisible lines that are present on healthy skin. Objective: The aim of the study was to elaborate this pattern in a comprehensive way. In IP patients with neurological signs brain lesions usually were localized and extended radially. The major function of this system is as a barrier against the external environment. 00021-4. Fungus that causes Athlete's. TIL Human skin is overlaid with Blaschko’s Lines, a pattern of stripes covering the body from head to toe, invisible unless under UV light or if certain skin conditions manifest them mentalfloss. What are the features of epidermal naevus? Linear epidermal naevus. The lines do not follow blood vessels, nerves, or other structures in the body. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. Moreover, the clinical and histopathologic overlap between the entities of blaschkitis and lichen striatus is explored. Blaschko’s Lines. (B) verrucous formation on the middle digit (3-months-old). Four other patterns of mosaicism are also discussed: blocklike, phylloid, large patches. Dear Editor, Lichen striatus (LS) is a self-limiting linear dermatosis that predominantly affects children aged 5 months to 15 years and is distributed along the lines of Blaschko. Type 1a and 1b in the image below are the most typically seen.